Animation of protein-folding chaperonin molecule TRiC

Courtesy of Judith Frydman
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This animated video shows the twisting motion of one of the two rings in the protein-folding chaperonin molecule TRiC. Although only one ring is shown here, both rings move in the same manner, similar to the rotational way the aperture of a camera moves.

The rings sit back to back, forming a barrel-shaped structure with openings at either end. When either ring opens or closes, the entire rest of the molecule also moves. The interior of the molecule is where the protein gets folded. Both rings are shut tight during the folding process.