Lawrence Wein’s main research interests are in manufacturing, health care, and homeland security. In all three areas, he has published widely and affected practice. His workload regulating release policy was widely adopted throughout the semiconductor industry. His HIV work on drug-switching policies led to a successful multi-center clinical trial. In the field of homeland security, his smallpox work influenced the U.S. Government’s post-attack vaccination policy; his anthrax work led to nationwide plans to use postal workers to distribute antibiotics after a large attack; his botulinum toxin work was influential in intensifying the heat pasteurization process for milk, and his testimony before a congressional committee on his biometric analysis of the US-VISIT Program was instrumental in the switch from a two-finger to a ten-finger system.